Interrogating Interactions and Modifications of Histones in Live Cells

Xiao-Meng Li; Xiang David Li

doi:10.1016/j.chembiol.2018.01.003

Interrogating Interactions and Modifications of Histones in Live Cells

Cell Chem Biol. 2018 Jan 18;25(1):1-3. doi: 10.1016/j.chembiol.2018.01.003.

Authors

Xiao-Meng Li¹, Xiang David Li²

Affiliations

¹ Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
² Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China. Electronic address: xiangli@hku.hk.

PMID: 29351836
DOI: 10.1016/j.chembiol.2018.01.003

Abstract

In this issue of Cell Chemical Biology, new methods are reported to interrogate histone interactions and modifications. Kleiner et al. (2018) develop a chemical proteomics platform for profiling of direct, context-dependent histone-protein interactions in living cells, and Delachat et al. (2018) engineer fluorescent sensors for coexisting histone modifications in live stem cells.

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MeSH terms

Chromatin
Histone Code*
Histones / genetics*
Protein Processing, Post-Translational
Stem Cells

Substances

Chromatin
Histones