Nanoscale Imaging Reveals Big Role for Iron in Alzheimer's Disease

Scott Ayton; Simon A James; Ashley I Bush

doi:10.1016/j.chembiol.2017.10.002

Nanoscale Imaging Reveals Big Role for Iron in Alzheimer's Disease

Cell Chem Biol. 2017 Oct 19;24(10):1192-1194. doi: 10.1016/j.chembiol.2017.10.002.

Authors

Scott Ayton¹, Simon A James¹, Ashley I Bush²

Affiliations

¹ Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
² Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia. Electronic address: ashley.bush@florey.edu.au.

PMID: 29053948
DOI: 10.1016/j.chembiol.2017.10.002

Abstract

In this issue of Cell Chemical Biology, Telling et al. (2017) apply advanced X-ray microscopy techniques to reveal magnetite iron species in plaques from a mouse model of Alzheimer's disease. The characterization of abnormal iron chemistry in the disease model highlights the potential for iron to combine with the β-amyloid peptide and accelerate the disease process.

MeSH terms

Alzheimer Disease / diagnostic imaging*
Alzheimer Disease / metabolism*
Iron / metabolism*
Molecular Imaging*
Nanotechnology*

Substances

Iron