Abstract
Fluorescent probes are powerful tools for the investigations of reactive oxygen species (ROS) in living organisms by visualization and imaging. As one of the most important of the natural reactive oxygen species (ROS), hypochlorous acid (HClO) plays a crucial role in various physiological and pathological processes. We report herein a new redox-switchable NMOF of UiO-68-ol via a direct ligand modification approach. The obtained UiO-68-ol NPs, which contains organic-based molecular redox switches, exhibit excellent photophysical properties for biological application and can be highly sensitive and selective fluorescent probes to detect HClO species in living cells.
MeSH terms
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Animals
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Cell Line, Tumor
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Cysteine / metabolism
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Drug Carriers / chemical synthesis
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Drug Carriers / chemistry
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Drug Carriers / pharmacology*
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry
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Fluorescent Dyes / pharmacology*
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Hydrazines / metabolism
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Hypochlorous Acid / analysis*
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Ligands
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Metal-Organic Frameworks / chemical synthesis
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Metal-Organic Frameworks / chemistry
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Metal-Organic Frameworks / pharmacology*
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Mice
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Microscopy, Confocal / methods
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Molecular Imaging
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Nanoparticles / chemistry*
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Oxidation-Reduction
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Porosity
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Uranium Compounds / chemistry*
Substances
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Drug Carriers
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Fluorescent Dyes
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Hydrazines
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Ligands
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Metal-Organic Frameworks
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Uranium Compounds
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Hypochlorous Acid
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1,1-diethyl-2-hydroxy-2-nitrosohydrazine
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Cysteine
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uranium oxide