Reborn from the Ashes: Turning Organic Molecules to Antimicrobial Carbon Quantum Dots

Scott G Harroun; Jui-Yang Lai; Chih-Ching Huang; Shou-Kuan Tsai; Han-Jia Lin

doi:10.1021/acsinfecdis.7b00150

Reborn from the Ashes: Turning Organic Molecules to Antimicrobial Carbon Quantum Dots

ACS Infect Dis. 2017 Nov 10;3(11):777-779. doi: 10.1021/acsinfecdis.7b00150. Epub 2017 Sep 21.

Authors

Scott G Harroun¹, Jui-Yang Lai^{2

3

4}, Chih-Ching Huang^{5

6

7}, Shou-Kuan Tsai⁵, Han-Jia Lin^{5

6}

Affiliations

¹ Department of Chemistry, Université de Montréal , 2900 Boulevard Édouard-Montpetit, Montréal, Québec H3C 3J7, Canada.
² Institute of Biochemical and Biomedical Engineering, Chang Gung University , 259 Wenhua 1st Road, Taoyuan, 33302, Taiwan.
³ Department of Ophthalmology, Chang Gung Memorial Hospital , 5 Fuxing Street, Taoyuan, 33305, Taiwan.
⁴ Department of Materials Engineering, Ming Chi University of Technology , 84 Gungjuan Road, New Taipei City, 24301, Taiwan.
⁵ Department of Bioscience and Biotechnology, National Taiwan Ocean University , 2 Beining Road, Keelung, 20224, Taiwan.
⁶ Center of Excellence for the Oceans, National Taiwan Ocean University , 2 Beining Road, Keelung, 20224, Taiwan.
⁷ School of Pharmacy, College of Pharmacy, Kaohsiung Medical University , 100 Shih-Chuan 1st Road, Kaohsiung, 80708, Taiwan.

PMID: 28933816
DOI: 10.1021/acsinfecdis.7b00150

Abstract

Using polyamines as the initial organic raw material and by applying simple pyrolysis methods, super cationic carbon quantum dots (CQDs) can easily be made. Since polyamines are natural products and the synthesis procedure is green, these polyamine-derived CQDs display low toxicity and high biocompatibility but possess high antibacterial activity. In addition, polyamine-derived CQDs display other unique properties, such as facilitation of wound healing and passage through the tight junction, which make them a very promising bactericide in future clinical applications.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology*
Bacteria / drug effects
Carbon / chemistry*
Polyamines / chemistry
Quantum Dots / chemistry*

Substances

Anti-Bacterial Agents
Polyamines
Carbon