Water instability is a crucial limiting factor in the practical application of most fluorescent metal-organic frameworks (MOFs). Here, by introducing a fascinating double-helical structure generated through dense stacking of organic ligands, a water-stable fluorescence MOF has been synthesized, namely, [Cd2(tib)2(bda)2]·(solvent)n (1) [tib =1,3,5-tris(1-imidazolyl) benzene; H2bda = 2,2'-biphenyl dicarboxylic acid]. This helical structure helps to enhance the stability of 1 against common organic solvents and water, even acid/base aqueous solutions with a pH value ranging from 3 to 11. Furthermore, this material can be a potential fluorescent sensor for ketones.