A TOGgle for Tension at Kinetochores

Dhanya K Cheerambathur; Bram Prevo; Arshad Desai

doi:10.1016/j.cell.2016.05.060

A TOGgle for Tension at Kinetochores

Cell. 2016 Jun 2;165(6):1316-1318. doi: 10.1016/j.cell.2016.05.060.

Authors

Dhanya K Cheerambathur¹, Bram Prevo¹, Arshad Desai²

Affiliations

¹ Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, CA 92093, USA; Ludwig Institute for Cancer Research, San Diego, CA 92093, USA.
² Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, CA 92093, USA; Ludwig Institute for Cancer Research, San Diego, CA 92093, USA. Electronic address: abdesai@ucsd.edu.

Abstract

Differential stability of kinetochore-microtubule attachments at low versus high tension is critical for accurate chromosome segregation. Miller et al. find that a TOG domain microtubule-binding protein imparts intrinsic tension selectivity to kinetochore-microtubule attachments.

Publication types

Comment

MeSH terms

Chromosome Segregation*
Kinetochores*
Microtubules / genetics
Spindle Apparatus / metabolism

Grants and funding

R01 GM074215/GM/NIGMS NIH HHS/United States