Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed

Trends Biochem Sci. 2016 Jun;41(6):475-477. doi: 10.1016/j.tibs.2016.04.007. Epub 2016 May 4.

Abstract

Two-pore channels (TPCs) are intracellular Ca(2+)-permeable ion channels that are expressed on acidic Ca(2+) stores. They are co-regulated by voltage and Ca(2+) in plant vacuoles and by the second messenger NAADP in animal endo-lysosomes. Two new studies of plant TPC structures reveal essential features of their architecture and provide mechanistic insight into their workings.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / genetics
  • Arabidopsis / metabolism*
  • Arabidopsis Proteins / chemistry*
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism
  • Binding Sites
  • Calcium / metabolism*
  • Calcium Channels / chemistry*
  • Calcium Channels / genetics
  • Calcium Channels / metabolism
  • Calcium Signaling
  • Crystallography, X-Ray
  • Endosomes / metabolism
  • Gene Expression
  • Ion Channel Gating
  • Lysosomes / metabolism
  • NADP / analogs & derivatives*
  • NADP / chemistry
  • NADP / metabolism
  • Protein Binding
  • Protein Conformation, alpha-Helical
  • Protein Interaction Domains and Motifs
  • Vacuoles / chemistry
  • Vacuoles / metabolism*

Substances

  • Arabidopsis Proteins
  • Calcium Channels
  • TPC1 protein, Arabidopsis
  • NADP
  • NAADP
  • Calcium