Abstract
Two-pore channels (TPCs) are intracellular Ca(2+)-permeable ion channels that are expressed on acidic Ca(2+) stores. They are co-regulated by voltage and Ca(2+) in plant vacuoles and by the second messenger NAADP in animal endo-lysosomes. Two new studies of plant TPC structures reveal essential features of their architecture and provide mechanistic insight into their workings.
Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Arabidopsis / genetics
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Arabidopsis / metabolism*
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Arabidopsis Proteins / chemistry*
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Arabidopsis Proteins / genetics
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Arabidopsis Proteins / metabolism
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Binding Sites
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Calcium / metabolism*
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Calcium Channels / chemistry*
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Calcium Channels / genetics
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Calcium Channels / metabolism
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Calcium Signaling
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Crystallography, X-Ray
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Endosomes / metabolism
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Gene Expression
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Ion Channel Gating
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Lysosomes / metabolism
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NADP / analogs & derivatives*
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NADP / chemistry
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NADP / metabolism
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Protein Binding
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Protein Conformation, alpha-Helical
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Protein Interaction Domains and Motifs
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Vacuoles / chemistry
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Vacuoles / metabolism*
Substances
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Arabidopsis Proteins
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Calcium Channels
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TPC1 protein, Arabidopsis
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NADP
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NAADP
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Calcium