Synthesis and Characterization of a "Turn-On" photoCORM for Trackable CO Delivery to Biological Targets

Samantha J Carrington; Indranil Chakraborty; Jenna M L Bernard; Pradip K Mascharak

doi:10.1021/ml500399r

Synthesis and Characterization of a "Turn-On" photoCORM for Trackable CO Delivery to Biological Targets

ACS Med Chem Lett. 2014 Nov 17;5(12):1324-8. doi: 10.1021/ml500399r. eCollection 2014 Dec 11.

Authors

Samantha J Carrington¹, Indranil Chakraborty¹, Jenna M L Bernard², Pradip K Mascharak¹

Affiliations

¹ Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States.
² Department of Chemistry, University of California , Berkeley, California 94720, United States.

Abstract

A designed photoactive CO releasing molecule (photoCORM), namely, fac-[MnBr(CO)3(pbt)] (1, pbt = 2-(2-pyridyl)benzothiazole), promotes CO-induced death of MDA-MB-231 human breast cancer cells upon illumination with broadband visible light. The CO release from this photoCORM can be tracked by rise in fluorescence within the cellular matrix due to deligation of the pbt ligand. The results of this study suggest the potential of 1 in eradication of cancer cells through CO delivery.

Keywords: CO delivery; Carbon monoxide; apoptosis; fluorescence tracking; photoactive metal carbonyls.