Aspartame-stabilized gold-silver bimetallic biocompatible nanostructures with plasmonic photothermal properties, antibacterial activity, and long-term stability

J Am Chem Soc. 2014 Dec 17;136(50):17394-7. doi: 10.1021/ja510435u. Epub 2014 Dec 9.

Abstract

Gold-silver core-shell nanoparticles stabilized with a common sweetener, aspartame (AuNP@Ag@Asm), combine the antimicrobial properties of silver with the photoinduced plasmon-mediated photothermal effects of gold. The particles were tested with several bacterial strains, while biocompatibility was verified with human dermal fibroblasts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Aspartame / chemistry*
  • Aspartame / pharmacology
  • Drug Stability
  • Fibroblasts / drug effects
  • Gold / chemistry*
  • Humans
  • Metal Nanoparticles / chemistry*
  • Microbial Sensitivity Tests
  • Microscopy, Electron, Transmission
  • Molecular Structure
  • Silver / chemistry*
  • Staphylococcus aureus / drug effects*
  • Time Factors

Substances

  • Anti-Bacterial Agents
  • Silver
  • Gold
  • Aspartame