Highly active macromolecular prodrugs inhibit expression of the hepatitis C virus genome in the host cells

Pau Ruiz-Sanchis; Benjamin M Wohl; Anton A A Smith; Kaja Zuwala; Jesper Melchjorsen; Martin Tolstrup; Alexander N Zelikin

doi:10.1002/adhm.201400307

Highly active macromolecular prodrugs inhibit expression of the hepatitis C virus genome in the host cells

Adv Healthc Mater. 2015 Jan 7;4(1):65-8. doi: 10.1002/adhm.201400307. Epub 2014 Aug 7.

Authors

Pau Ruiz-Sanchis¹, Benjamin M Wohl, Anton A A Smith, Kaja Zuwala, Jesper Melchjorsen, Martin Tolstrup, Alexander N Zelikin

Affiliation

¹ Department of Chemistry, Aarhus University, Aarhus, C 8000, Denmark.

PMID: 25132665
DOI: 10.1002/adhm.201400307

Abstract

Efficacious, potent, and at the same time nontoxic macromolecular prodrugs of ribavirin are designed taking advantage over prodrug activation by the intracellular milieu. Activity of these prodrugs is illustrated in the cells hosting hepatitis C virus replication and also in the cells implicated in the inflammatory response to the viral infection.

Keywords: drug delivery; hepatitis C virus; polymers; prodrugs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents* / chemical synthesis
Antiviral Agents* / chemistry
Antiviral Agents* / pharmacology
Cell Line
Gene Expression Regulation, Viral / drug effects*
Genome, Viral*
Hepacivirus / genetics
Hepacivirus / metabolism*
Hepatitis C / drug therapy*
Hepatitis C / genetics
Hepatitis C / metabolism
Hepatitis C / pathology
Humans
Polymethacrylic Acids* / chemical synthesis
Polymethacrylic Acids* / chemistry
Polymethacrylic Acids* / pharmacology
Prodrugs* / chemical synthesis
Prodrugs* / chemistry
Prodrugs* / pharmacology
Ribavirin* / analogs & derivatives
Ribavirin* / chemical synthesis
Ribavirin* / chemistry
Ribavirin* / pharmacology

Substances

Antiviral Agents
Polymethacrylic Acids
Prodrugs
polymethacrylic acid
Ribavirin