Thin endometrium in donor oocyte recipients: enigma or obstacle for implantation?

Fertil Steril. 2013 Nov;100(5):1289-95. doi: 10.1016/j.fertnstert.2013.07.1966. Epub 2013 Aug 15.

Abstract

Objective: To evaluate the combined effect of endometrial thickness and anatomic uterine factors on clinical outcome in oocyte donation recipients.

Design: Retrospective analysis of oocyte donation cycles conducted between 2005 and 2010.

Setting: Two private IVF centers.

Patient(s): A total of 737 donor oocyte cycles.

Intervention(s): None.

Main outcome measure(s): Clinical pregnancy and live birth rates.

Result(s): No statistically significant difference was found in clinical pregnancy rates and live birth rates in cycles with endometrial thickness <6 mm compared with those with endometrial thickness >10 mm. However, a relatively high rate of live births was found within a medium range of endometrial thickness (8.2-10 mm). All intrauterine adhesion cases occurred in cycles with thinner endometrium.

Conclusion(s): No statistically significant difference was found in clinical pregnancy rates and live birth rates in cycles with endometrial thickness <6 mm compared with those with thickness >6 mm. A relatively high rate of live births was found within a medium range of endometrial thickness (9.1-10 mm).

Keywords: Endometrial thickness; estrogen replacement therapy; oocyte donation; uterine factors.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Abortion, Spontaneous / etiology
  • Adult
  • Chi-Square Distribution
  • Embryo Implantation*
  • Embryo Transfer* / adverse effects
  • Endometrium / diagnostic imaging*
  • Endometrium / physiopathology
  • Female
  • Fertilization in Vitro
  • Humans
  • Live Birth
  • Logistic Models
  • Middle Aged
  • Oocyte Donation* / adverse effects
  • Pregnancy
  • Pregnancy Rate
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome
  • Ultrasonography
  • Young Adult