Fluorescent multiblock π-conjugated polymer nanoparticles for in vivo tumor targeting

Adv Mater. 2013 Aug 27;25(32):4504-10. doi: 10.1002/adma.201301656. Epub 2013 Jun 24.

Abstract

Highly fluorescent multiblock conjugated polymer nanoparticles with folic acid surface ligands are highly effective for bioimaging and in vivo tumor targeting. The targeted nanoparticles were preferentially localized in tumor cells in vivo, thereby illustrating their potential for diagnostic and therapeutic applications.

Keywords: block copolymers; conjugated polymers; fluorescent bioimaging; nanoparticles; tumor targeting.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Fluorescent Dyes* / analysis
  • Folic Acid / analysis
  • Humans
  • Mice
  • Mice, Nude
  • Nanoparticles* / analysis
  • Nanoparticles* / ultrastructure
  • Neoplasms / diagnosis*
  • Optical Imaging / methods*
  • Polymers* / analysis
  • Whole Body Imaging / methods*

Substances

  • Fluorescent Dyes
  • Polymers
  • Folic Acid