Poly(2-oxazoline)s--are they more advantageous for biomedical applications than other polymers?

Macromol Rapid Commun. 2012 Oct 15;33(19):1648-62. doi: 10.1002/marc.201200453.

Abstract

Poly(2-alkyl-2-oxazoline)s are biocompatible polymers with polypeptide-isomeric structures that are attracting increasing interest as biomaterials for drug, gene, protein, and radionuclide delivery. They are, however, still relatively new in comparison to other classes of hydrophilic water-soluble polymers already established for such use, including poly(ethylene oxide), polyvinylpyrrolidone, and polymethacrylamides such as poly[N-(2-hydroxypropyl)methacrylamide]. This feature article critically compares the synthetic aspects and physicochemical and biological properties of poly(2-alkyl-2-oxazoline)s and these commonly studied polymers in terms of their suitability for biomedical applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry
  • Drug Carriers / chemistry
  • Hydrophobic and Hydrophilic Interactions
  • Oxazoles / chemical synthesis
  • Oxazoles / chemistry*
  • Polymers / chemistry*
  • Solutions / chemistry
  • Water / chemistry

Substances

  • Biocompatible Materials
  • Drug Carriers
  • Oxazoles
  • Polymers
  • Solutions
  • poly(2-oxazoline)
  • Water