Ruthenium-catalyzed oxidative C(sp2)-H bond hydroxylation: site-selective C-O bond formation on benzamides

Vedhagiri S Thirunavukkarasu; Jonathan Hubrich; Lutz Ackermann

doi:10.1021/ol3018819

Ruthenium-catalyzed oxidative C(sp2)-H bond hydroxylation: site-selective C-O bond formation on benzamides

Org Lett. 2012 Aug 17;14(16):4210-3. doi: 10.1021/ol3018819. Epub 2012 Aug 2.

Authors

Vedhagiri S Thirunavukkarasu¹, Jonathan Hubrich, Lutz Ackermann

Affiliation

¹ Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany.

PMID: 22853552
DOI: 10.1021/ol3018819

Abstract

Well-defined ruthenium carboxylate complexes enabled unprecedented ruthenium-catalyzed C(sp(2))-H hydroxylations on benzamides with PhI(OAc)(2) as the oxidant at a remarkably low catalyst loading of 1.0 mol %.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzamides / chemical synthesis*
Benzamides / chemistry
Carboxylic Acids / chemistry
Catalysis
Hydroxylation
Molecular Structure
Oxidation-Reduction
Ruthenium / chemistry*

Substances

Benzamides
Carboxylic Acids
Ruthenium