Platelet function disorders and menorrhagia in adolescents: a review of laboratory diagnosis

Nancy A Sokkary; Lakshmi Venkateswaran; Jennifer E Dietrich; Jun Teruya

doi:10.1016/j.jpag.2012.01.004

Platelet function disorders and menorrhagia in adolescents: a review of laboratory diagnosis

J Pediatr Adolesc Gynecol. 2012 Aug;25(4):233-7. doi: 10.1016/j.jpag.2012.01.004.

Authors

Nancy A Sokkary¹, Lakshmi Venkateswaran, Jennifer E Dietrich, Jun Teruya

Affiliation

¹ Department of Pediatric and Adolescent Gynecology, Baylor College of Medicine, Houston, Texas, USA. nsokkary@yahoo.com

PMID: 22840932
DOI: 10.1016/j.jpag.2012.01.004

Abstract

This article provides an overview of the prevalence and pathophysiology of platelet function disorders (PFDs) in adolescents with menorrhagia. In addition, this article reviews the various testing modalities employed for diagnosing PFDs including platelet aggregometry, platelet function analyzer (PFA-100), platelet electron microscopy (EM), flow cytometry, and thromboelastography (TEG), discuss their utility and drawbacks, and allude to the recent recommendations and consensus statements about some of these modalities. Finally, the authors have sketched out a diagnostic algorithm for platelet function testing, which will guide treating physicians to a step-wise approach while evaluating adolescents with menorrhagia for PFDs.

Publication types

Review

MeSH terms

Adolescent
Blood Platelet Disorders / complications*
Blood Platelet Disorders / diagnosis*
Female
Humans
Menorrhagia / etiology*
Platelet Function Tests