Abstract
The focus of our decade-long National Institutes of Health-sponsored NURSA Proteomics Atlas was to catalog and understand the composition of the steady-state interactome for all nuclear receptor coregulator complexes in a human cell. In this Perspective, we present a summary of the proteomics of coregulator complexes with examples of how one might use the NURSA data for future exploitation. The application of this information to the identification of the coregulator proteins that contribute to the molecular basis of polygenic diseases is emphasized.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Carbohydrate Metabolism
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Histone Deacetylases / metabolism
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Humans
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Intracellular Signaling Peptides and Proteins / metabolism
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Liver / metabolism
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Metabolic Diseases / genetics
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Metabolic Diseases / metabolism
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Nuclear Receptor Coactivators / metabolism
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Nuclear Receptor Subfamily 1, Group F, Member 1 / metabolism
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Oncogene Proteins / metabolism
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Protein Deglycase DJ-1
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Protein Interaction Mapping*
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Proteomics
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Repressor Proteins / metabolism
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Sin3 Histone Deacetylase and Corepressor Complex / metabolism
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Trans-Activators
Substances
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Intracellular Signaling Peptides and Proteins
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MTA1 protein, human
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Nuclear Receptor Coactivators
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Nuclear Receptor Subfamily 1, Group F, Member 1
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Oncogene Proteins
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RORA protein, human
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Receptors, Cytoplasmic and Nuclear
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Repressor Proteins
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Trans-Activators
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PARK7 protein, human
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Protein Deglycase DJ-1
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Histone Deacetylases
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Sin3 Histone Deacetylase and Corepressor Complex