Effect of HMG-CoA reductase inhibitors on antimicrobial susceptibilities for gram-negative rods

J Basic Microbiol. 2013 Apr;53(4):336-9. doi: 10.1002/jobm.201100614. Epub 2012 Jun 26.

Abstract

Epidemiologic evidence suggests a beneficial effect of HMG-CoA reductase inhibitors (statins) in sepsis, and in-vitro data exist for antimicrobial activity of statins against some bacteria and fungi. We examined whether statin exposure at physiologic concentrations enhances activity of selected antimicrobials against Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. Broth microdilution was performed with and without dose-ranging concentrations of lovastatin, fluvastatin, atorvastatin, pravastatin and simvastatin. No effects on antimicrobial activity were demonstrated.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Drug Interactions*
  • Gram-Negative Aerobic Rods and Cocci / drug effects*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors