Abstract
Tripartilactam, a structurally unprecedented cyclobutane-bearing tricyclic lactam metabolite, was discovered from Streptomyces sp. isolated from a brood ball of the dung beetle, Copris tripartitus. The structure of this compound was elucidated by the combination of NMR, MS, UV, and IR spectroscopy and multistep chemical derivatization. Tripartilactam was evaluated as a Na(+)/K(+) ATPase inhibitor (IC(50) = 16.6 μg/mL).
© 2012 American Chemical Society
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line, Tumor
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Cell Survival / drug effects
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Coleoptera / microbiology*
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Cyclobutanes / chemistry*
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Cyclobutanes / isolation & purification
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Cyclobutanes / pharmacology
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Feces / microbiology*
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Humans
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Lactams / chemistry*
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Lactams / isolation & purification
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Lactams / pharmacology
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Molecular Structure
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Sodium Potassium Chloride Symporter Inhibitors / chemistry*
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Sodium Potassium Chloride Symporter Inhibitors / isolation & purification
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Sodium Potassium Chloride Symporter Inhibitors / pharmacology
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Streptomyces / chemistry*
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Streptomyces / isolation & purification
Substances
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Cyclobutanes
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Lactams
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Sodium Potassium Chloride Symporter Inhibitors
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tripartilactam