Abstract
α,β-Unsaturated carbonyl compounds are versatile intermediates in the synthesis of pharmaceuticals and biologically active compounds. Here, we report the discovery and application of Pd(DMSO)(2)(TFA)(2) as a catalyst for direct dehydrogenation of cyclohexanones and other cyclic ketones to the corresponding enones, using O(2) as the oxidant. The substrate scope includes heterocyclic ketones and several natural-product precursors.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Catalysis
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Chemistry Techniques, Synthetic
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Cyclohexanones / chemical synthesis
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Cyclohexanones / chemistry
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Hydrocarbons, Cyclic / chemical synthesis*
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Hydrocarbons, Cyclic / chemistry
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Ketones / chemical synthesis
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Ketones / chemistry*
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Oxygen / chemistry
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Palladium / chemistry*
Substances
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Cyclohexanones
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Hydrocarbons, Cyclic
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Ketones
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Palladium
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Oxygen