Rh-catalyzed transannulation of N-tosyl-1,2,3-triazoles with terminal alkynes

Org Lett. 2011 Jul 15;13(14):3746-9. doi: 10.1021/ol2014347. Epub 2011 Jun 21.

Abstract

The first transannulation of 1,2,3-triazoles with terminal alkynes into pyrroles is reported. The reaction proceeds in the presence of a Rh(2)(oct)(4)/AgOCOCF(3) binary catalyst system providing a straightforward approach to 1,2,4-trisubstituted pyrroles in good to excellent yields.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alkynes / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Molecular Structure
  • Pyrroles / chemical synthesis*
  • Pyrroles / chemistry
  • Rhodium / chemistry*
  • Triazoles / chemistry*

Substances

  • Alkynes
  • Pyrroles
  • Triazoles
  • Rhodium