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J Pediatr. 2011 Sep;159(3):458-465.e1-6. doi: 10.1016/j.jpeds.2011.02.036. Epub 2011 Apr 27.

Detecting, studying, and treating autism early: the one-year well-baby check-up approach.

Author information

  • 1Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA 92037, USA, kpierce@ucsd.edu

Abstract

OBJECTIVES:

To determine the feasibility of implementing a broadband screen at the 1-year check-up to detect cases of autism spectrum disorders (ASD), language delay (LD), and developmental delay (DD).

STUDY DESIGN:

The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist was distributed at every 1-year pediatric check-up; 137 pediatricians and 225 infants participated. Screens were scored immediately, and failures referred for further evaluation.

RESULTS:

Pediatricians screened 10 479 infants at the 1-year check-up; 184 infants who failed the screen were evaluated and tracked. To date, 32 infants received a provisional or final diagnosis of ASD, 56 of LD, nine of DD, and 36 of "other." Five infants who initially tested positive for ASD no longer met criteria at follow-up. The remainder of the sample was false positive results. Positive predictive value was estimated to be .75.

CONCLUSIONS:

The 1-Year Well-Baby Check-Up Approach shows promise as a simple mechanism to detect cases of ASD, LD, and DD at 1 year. This procedure offers an alternative to the baby sibling design as a mechanism to study autism prospectively, the results of which will enrich our understanding of autism at an early age.

Copyright © 2011 Mosby, Inc. All rights reserved.

PMID:
21524759
[PubMed - indexed for MEDLINE]
PMCID:
PMC3157595
Free PMC Article
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