Abstract
We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Biological Transport
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Cell Line, Tumor
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Folate Receptors, GPI-Anchored / metabolism
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Folic Acid / metabolism
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Gene Expression Regulation
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Gold / chemistry*
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Gold / metabolism*
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Humans
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Ligands
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Metal Nanoparticles*
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Nanotechnology / instrumentation*
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Receptors, Cell Surface / metabolism*
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Substrate Specificity
Substances
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Folate Receptors, GPI-Anchored
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Ligands
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Receptors, Cell Surface
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Gold
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Folic Acid