Palladium-catalyzed C-H functionalization of heteroarenes with aryl bromides and chlorides

Shunsuke Tamba; Youhei Okubo; Shota Tanaka; Daiki Monguchi; Atsunori Mori

doi:10.1021/jo101433g

Palladium-catalyzed C-H functionalization of heteroarenes with aryl bromides and chlorides

J Org Chem. 2010 Oct 15;75(20):6998-7001. doi: 10.1021/jo101433g.

Authors

Shunsuke Tamba¹, Youhei Okubo, Shota Tanaka, Daiki Monguchi, Atsunori Mori

Affiliation

¹ Department of Chemical Science and Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan.

PMID: 20857989
DOI: 10.1021/jo101433g

Abstract

Palladium-catalyzed C-H arylation of electron-enriched heteroarenes with aryl bromides and aryl chlorides proceeds in the presence of LiO-t-Bu as a base. The reaction allows one-pot synthesis of differently substituted 2,5-diarylthiazole with the same catalyst system by switching the solvent and the amount of base.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Hydrocarbons, Brominated / chemistry*
Hydrocarbons, Chlorinated / chemistry*
Molecular Structure
Organometallic Compounds / chemistry*
Palladium / chemistry*
Stereoisomerism
Thiazoles / chemical synthesis*
Thiazoles / chemistry*

Substances

Hydrocarbons, Brominated
Hydrocarbons, Chlorinated
Organometallic Compounds
Thiazoles
Palladium