Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027

Angew Chem Int Ed Engl. 2010 Oct 18;49(43):7926-8. doi: 10.1002/anie.201003369.

Authors

Xiaolei Chen¹, Zu-Feng Guo, Pok Man Lai, Kong Hung Sze, Zhihong Guo

Affiliation

¹ Department of Chemistry, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.

PMID: 20848627
DOI: 10.1002/anie.201003369

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aminoglycosides / metabolism*
Antibiotics, Antineoplastic / metabolism*
Bacteria / enzymology
Bacterial Proteins / genetics
Bacterial Proteins / metabolism*
Enediynes / metabolism*
Escherichia coli / genetics
Gene Expression
Polyketide Synthases / genetics
Polyketide Synthases / metabolism*

Substances

Aminoglycosides
Antibiotics, Antineoplastic
Bacterial Proteins
Enediynes
C 1027
Polyketide Synthases