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Muscle Nerve. 1991 Mar;14(3):233-6.

Steroid-responsive tubular aggregate myopathy.

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  • 1Department of Neurology, Rhode Island Hospital, Providence.


We report a man with an acute myalgia/cramp syndrome and tubular aggregates on his muscle biopsy. He was placed on prednisone and was found to be exquisitely sensitive to the drug, with changes of only 5 mg precipitating recurrence of symptoms. He was eventually tapered off all steroids, without symptoms, and repeat biopsy showed no tubular aggregates. We recommend similar patients be given a trial of high-dose steroids.

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