Substrate-controlled and organocatalytic asymmetric synthesis of carbocyclic amino acid dipeptide mimetics

Stephen Hanessian; Dilip K Maji; Subramaniyan Govindan; Riccardo Matera; Marina Tintelnot-Blomley

doi:10.1021/jo100017t

Substrate-controlled and organocatalytic asymmetric synthesis of carbocyclic amino acid dipeptide mimetics

J Org Chem. 2010 May 7;75(9):2861-76. doi: 10.1021/jo100017t.

Authors

Stephen Hanessian¹, Dilip K Maji, Subramaniyan Govindan, Riccardo Matera, Marina Tintelnot-Blomley

Affiliation

¹ Department of Chemistry, Université de Montréal, P.O. Box 6128, Station Centre-ville, Montréal, QC H3C 3J7, Canada. stephen.hanessian@umontreal.ca

PMID: 20392053
DOI: 10.1021/jo100017t

Abstract

The asymmetric synthesis of a carbocyclic delta-amino acid representing the P(2)/P(3) subunit of a nonpeptidic truncated peptidomimetic molecule is described relying on two independent approaches.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acids, Carbocyclic / chemistry*
Amino Acids / chemistry*
Biomimetic Materials / chemical synthesis*
Catalysis
Dipeptides / chemical synthesis*
Molecular Structure

Substances

Acids, Carbocyclic
Amino Acids
Dipeptides