Secondary metabolomics: natural products mass spectrometry goes global

Roland D Kersten; Pieter C Dorrestein

doi:10.1021/cb900187p

Secondary metabolomics: natural products mass spectrometry goes global

ACS Chem Biol. 2009 Aug 21;4(8):599-601. doi: 10.1021/cb900187p.

Authors

Roland D Kersten¹, Pieter C Dorrestein

Affiliation

¹ Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Center for Marine Biotechnology and Biomedicine, University of California,San Diego 92093, USA.

PMID: 19817465
DOI: 10.1021/cb900187p

Abstract

A global LC-MS metabolite analysis of wild-type Pseudomonas auerigunosa and mutants targeting the natural product pyochelin revealed the production of previously unknown metabolites, the 2-alkyl-4,5-dihydrothiazole-4-carboxylates.

MeSH terms

Animals
Biological Products / analysis*
Biological Products / chemistry
Biological Products / metabolism
Mass Spectrometry / methods*
Metabolomics / methods*
Phenols / chemistry
Phenols / metabolism
Pseudomonas aeruginosa / chemistry
Pseudomonas aeruginosa / metabolism*
Thiazoles / chemistry
Thiazoles / metabolism

Substances

Biological Products
Phenols
Thiazoles
pyochelin