Application of copper(II)-dipyridylphosphine catalyst in the asymmetric hydrosilylation of simple ketones in air

Xi-Chang Zhang; Yan Wu; Feng Yu; Fei-Fei Wu; Jing Wu; Albert S C Chan

doi:10.1002/chem.200900499

Application of copper(II)-dipyridylphosphine catalyst in the asymmetric hydrosilylation of simple ketones in air

Chemistry. 2009 Jun 8;15(24):5888-91. doi: 10.1002/chem.200900499.

Authors

Xi-Chang Zhang¹, Yan Wu, Feng Yu, Fei-Fei Wu, Jing Wu, Albert S C Chan

Affiliation

¹ College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310036, PR China.

PMID: 19418525
DOI: 10.1002/chem.200900499

Abstract

Ask a copper: A copper(II) salt/chiral dipyridylphosphine/PhSiH(3) system (see scheme) acts as a very effective and practical catalyst for the asymmetric reduction of heteroaromatic and other types of ketones in air with good-to-excellent enantioselectivities (up to 94%), giving many chiral alcohols that are intermediates for physiologically active compounds. Remarkable temperature effects were observed for some heteroaromatic ketones.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Air
Catalysis
Copper
Ketones / chemistry*
Models, Molecular
Molecular Structure
Organometallic Compounds / chemistry*
Silanes
Stereoisomerism

Substances

Ketones
Organometallic Compounds
Silanes
Copper