Abstract
Rhodium-catalyzed C-H insertion of hydroxylamine-derived sulfamate esters makes possible the synthesis of unique oxathiadiazinane heterocycles, which upon mild reduction furnish differentially substituted 1,2-diamine products. This highly chemo- and diastereoselective transformation underscores the power of catalytic C-H functionalization as a general approach to C-N bond construction.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amination
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Carbon / chemistry
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Catalysis
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Diamines / chemical synthesis*
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Esters / chemistry*
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Hydrogen / chemistry
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Hydroxylamine / chemistry*
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Models, Chemical
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Nitrogen / chemistry
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Oxidation-Reduction
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Rhodium / chemistry*
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Stereoisomerism
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Sulfonamides / chemistry*
Substances
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Diamines
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Esters
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Sulfonamides
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Hydroxylamine
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Carbon
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Hydrogen
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Rhodium
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Nitrogen