The pathophysiology of long-term neuromuscular and cognitive outcomes following critical illness

Margaret S Herridge; Jane Batt; Ramona O Hopkins

doi:10.1016/j.ccc.2007.11.002

The pathophysiology of long-term neuromuscular and cognitive outcomes following critical illness

Crit Care Clin. 2008 Jan;24(1):179-99, x. doi: 10.1016/j.ccc.2007.11.002.

Authors

Margaret S Herridge¹, Jane Batt, Ramona O Hopkins

Affiliation

¹ Pulmonary and Critical Care Medicine, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada M5G 2C4. margaret.herridge@uhn.on.ca

PMID: 18241785
DOI: 10.1016/j.ccc.2007.11.002

Abstract

Despite the recent and marked improvement in short-term mortality after critical illness, significant morbidities persist for many patients following hospital discharge. This article discusses the risk factors for muscle, nerve, and brain dysfunction after critical illness and preliminary basic science data to support possible pathophysiologic mechanisms mediating this disability. Additionally, it presents a roadmap outlining future directions in this area of research.

Publication types

Review

MeSH terms

Animals
Cognition Disorders / diagnosis
Cognition Disorders / etiology
Cognition Disorders / physiopathology*
Humans
Neuromuscular Diseases / diagnosis
Neuromuscular Diseases / etiology
Neuromuscular Diseases / physiopathology*
Polyneuropathies* / complications
Polyneuropathies* / diagnosis
Polyneuropathies* / physiopathology
Systemic Inflammatory Response Syndrome / etiology
Systemic Inflammatory Response Syndrome / metabolism
Systemic Inflammatory Response Syndrome / physiopathology*