Abstract
[reaction: see text] A convergent, biomimetic total synthesis of the immunosuppressant polyketides SNF4435 C and D is described. The synthetic pathway features a stereo- and regioselective [3,3]-sigmatropic rearrangement as well as a high-yielding Stille coupling/8pi-6pi electrocyclization cascade.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Crystallography, X-Ray
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Models, Molecular
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Molecular Structure
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Nitrites / chemistry
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Nitro Compounds / chemical synthesis*
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Nitro Compounds / chemistry
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Pyrones / chemical synthesis*
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Pyrones / chemistry
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Stereoisomerism
Substances
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Nitrites
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Nitro Compounds
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Pyrones
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SNF 4435C
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SNF 4435D