Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta

J Nat Prod. 2005 Aug;68(8):1253-5. doi: 10.1021/np0402221.

Abstract

A new scalarane-type pentacyclic sesterterpene, sesterstatin 6 (6), was isolated in 8.3 x 10(-7)% yield from the Republic of Maldives marine sponge Hyrtios erecta. The structure was elucidated by analyses of HRMS and high-field 2-D NMR spectra. Sesterstatin 6 showed significant cancer cell growth inhibition against murine P388 lymphocytic leukemia and a series of human tumor cell lines (ED50 0.17 microg/mL, GI50 1.8-8.9 x 10(-1) microg/mL) and proved to be the most inhibitory of the series.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • Indian Ocean
  • Leukemia P388
  • Mice
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Terpenes
  • sesterstatin 6