Catalytic C-C bond formation via capture of hydrogenation intermediates

Hye-Young Jang; Michael J Krische

doi:10.1021/ar020108e

Catalytic C-C bond formation via capture of hydrogenation intermediates

Acc Chem Res. 2004 Sep;37(9):653-61. doi: 10.1021/ar020108e.

Authors

Hye-Young Jang¹, Michael J Krische

Affiliation

¹ University of Texas at Austin, Department of Chemistry and Biochemistry, Austin, Texas 78712, USA.

PMID: 15379581
DOI: 10.1021/ar020108e

Abstract

Although catalytic hydrogenation has been practiced for over a century, use of hydrogen as a terminal reductant in catalytic C-C bond formation has been restricted to processes involving migratory insertion of carbon monoxide, e.g., alkene hydroformylation and related Fischer-Tropsch-type reactions. In an effort to develop hydrogenation as a new method for catalytic cross-coupling, a catalytic system enabling capture of hydrogenation intermediates was recently developed in our lab. These results support the feasibility of developing a broad new family of hydrogen-mediated C-C bond formations.