No-D NMR spectroscopy as a convenient method for titering organolithium (RLi), RMgX, and LDA solutions

Thomas R Hoye; Brian M Eklov; Mikhail Voloshin

doi:10.1021/ol049145r

No-D NMR spectroscopy as a convenient method for titering organolithium (RLi), RMgX, and LDA solutions

Org Lett. 2004 Jul 22;6(15):2567-70. doi: 10.1021/ol049145r.

Authors

Thomas R Hoye¹, Brian M Eklov, Mikhail Voloshin

Affiliation

¹ Department of Chemistry, 207 Pleasant Street, SE, University of Minnesota, Minneapolis, Minnesota 55455, USA. hoye@chem.umn.edu

PMID: 15255692
DOI: 10.1021/ol049145r

Abstract

[reaction: see text] The concentration of organolithium, organomagnesium halide, and lithium diisopropylamide solutions can be reliably determined using No-D NMR spectroscopy by integration against the added internal standard 1,5-cyclooctadiene (COD) (or cyclooctene). In addition, common impurities and degradation products can be assessed.

Publication types

Comparative Study
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Lithium / chemistry*
Magnesium / chemistry*
Magnetic Resonance Spectroscopy / instrumentation
Magnetic Resonance Spectroscopy / methods*
Molecular Structure
Organometallic Compounds / chemistry*

Substances

Organometallic Compounds
Lithium
Magnesium

Abstract

Publication types

MeSH terms

Substances

Grants and funding