Abstract
This study examined the effect of a podophyllotoxin derivative, deoxypodophyllotoxin (anthricin), which is a medicinal herb product isolated from Anthriscus sylvestris Hoffm. Deoxypodophyllotoxin was tested in a rat PCA (passive cutaneous anaphylaxis) assay by administering deoxypodophyllotoxin intraperitoneally (1.0 to 10 mg/kg, i.p.) and intravenously (0.25 to 1.0 mg/kg, i.v.). Deoxypodophyllotoxin dose-dependently inhibited the PCA reaction activated by anti-dinitrophenyl (DNP) IgE. The PCA inhibitory activity of deoxypodophyllotoxin was stronger than those of prednisolone and indomethacin, which were used as positive controls. These results suggest that deoxypodophyllotoxin may be beneficial in regulating the immediate-type allergic reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apiaceae*
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Dose-Response Relationship, Drug
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Drugs, Chinese Herbal
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Hypersensitivity, Immediate / prevention & control*
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Injections, Intraperitoneal
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Injections, Intravenous
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Lignans / administration & dosage
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Lignans / pharmacology*
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Lignans / therapeutic use
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Male
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Passive Cutaneous Anaphylaxis / drug effects
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Plant Roots
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Podophyllotoxin / administration & dosage
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Podophyllotoxin / analogs & derivatives*
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Podophyllotoxin / pharmacology*
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Podophyllotoxin / therapeutic use
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Rats
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Rats, Sprague-Dawley
Substances
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Drugs, Chinese Herbal
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Lignans
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Plant Extracts
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deoxypodophyllotoxin
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Podophyllotoxin