Overexpression of the BCL2 gene in a Sertoli-Leydig cell tumor of the ovary: a pathologic and cytogenetic study

Lisa Truss; Sheila M Dobin; Arundati Rao; Ludvik R Donner

doi:10.1016/s0165-4608(03)00276-0

Overexpression of the BCL2 gene in a Sertoli-Leydig cell tumor of the ovary: a pathologic and cytogenetic study

Cancer Genet Cytogenet. 2004 Jan 15;148(2):118-22. doi: 10.1016/s0165-4608(03)00276-0.

Authors

Lisa Truss¹, Sheila M Dobin, Arundati Rao, Ludvik R Donner

Affiliation

¹ Scott, Sherwood and Brindley Foundation, The Texas A and M University System Health Science Center, College of Medicine, 2401 South 31st Street, Temple, TX 76508, USA.

PMID: 14734221
DOI: 10.1016/s0165-4608(03)00276-0

Abstract

A case of virilizing ovarian Sertoli-Leydig cell tumor overexpressing the BCL2 gene and including a novel clonal chromosomal rearrangement of chromosome 18, der(5)t(5;18)(p13;q12),+6,+12, der(18)r(5;18)(p15.3p13;p11.3q12) is described. Further studies of these rare tumors are necessary to ascertain the significance of the findings.

MeSH terms

Adolescent
Chromosome Aberrations*
Cytogenetic Analysis
Female
Humans
Immunohistochemistry
Proto-Oncogene Proteins c-bcl-2 / biosynthesis
Proto-Oncogene Proteins c-bcl-2 / genetics*
Sertoli-Leydig Cell Tumor / genetics*
Sertoli-Leydig Cell Tumor / pathology

Substances

Proto-Oncogene Proteins c-bcl-2