Antifungal 3-hydroxy fatty acids from Lactobacillus plantarum MiLAB 14

Appl Environ Microbiol. 2003 Dec;69(12):7554-7. doi: 10.1128/AEM.69.12.7554-7557.2003.

Abstract

We report the identification and chemical characterization of four antifungal substances, 3-(R)-hydroxydecanoic acid, 3-hydroxy-5-cis-dodecenoic acid, 3-(R)-hydroxydodecanoic acid and 3-(R)-hydroxytetradecanoic acid, from Lactobacillus plantarum MiLAB 14. The concentrations of the 3-hydroxy fatty acids in the supernatant followed the bacterial growth. Racemic mixtures of the saturated 3-hydroxy fatty acids showed antifungal activity against different molds and yeasts with MICs between 10 and 100 micrograms ml-1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Culture Media, Conditioned
  • Decanoic Acids / chemistry
  • Decanoic Acids / pharmacology*
  • Fungi / drug effects*
  • Lactobacillus / genetics
  • Lactobacillus / growth & development
  • Lactobacillus / isolation & purification
  • Lactobacillus / metabolism*
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Oleaceae / microbiology
  • Sequence Analysis, DNA

Substances

  • Antifungal Agents
  • Culture Media, Conditioned
  • Decanoic Acids

Associated data

  • GENBANK/AY383631