Abstract
The structure of tubulin shows paclitaxel (Taxol(R)) binding to a pocket in beta tubulin on the microtubule's inner surface, which counteracts the effects of GTP hydrolysis occurring on the other side of the monomer.
MeSH terms
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Amino Acid Sequence
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Animals
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Antineoplastic Agents, Phytogenic / pharmacology*
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Humans
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Microtubules / drug effects*
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Microtubules / enzymology
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Microtubules / ultrastructure
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Molecular Sequence Data
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Paclitaxel / pharmacology*
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Protein Conformation
Substances
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Antineoplastic Agents, Phytogenic
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Paclitaxel