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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 1
1995 10
1996 8
1997 11
1998 10
1999 9
2000 9
2001 13
2002 17
2003 24
2004 26
2005 18
2006 28
2007 31
2008 38
2009 43
2010 32
2011 44
2012 56
2013 70
2014 81
2015 83
2016 82
2017 99
2018 104
2019 80
2020 80
2021 76
2022 75
2023 69
2024 29

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1,196 results

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Page 1
Human FOX gene family (Review).
Katoh M, Katoh M. Katoh M, et al. Int J Oncol. 2004 Nov;25(5):1495-500. Int J Oncol. 2004. PMID: 15492844 Review.
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOX …
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD …
FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma.
Wang Y, Lyu Z, Qin Y, Wang X, Sun L, Zhang Y, Gong L, Wu S, Han S, Tang Y, Jia Y, Kwong DL, Kam N, Guan XY. Wang Y, et al. Theranostics. 2020 Sep 16;10(25):11535-11548. doi: 10.7150/thno.45261. eCollection 2020. Theranostics. 2020. PMID: 33052231 Free PMC article.
However, its function in the tumor microenvironment (TME) remains largely unexplored. In this study, we characterized the prognostic value of FOXO1 and the interaction between tumor-derived FOXO1 and M2 macrophages in esophageal squamous cell carcinoma (ESCC). ...CS …
However, its function in the tumor microenvironment (TME) remains largely unexplored. In this study, we characterized the prognostic value o …
Molecular testing of rhabdomyosarcoma in clinical trials to improve risk stratification and outcome: A consensus view from European paediatric Soft tissue sarcoma Study Group, Children's Oncology Group and Cooperative Weichteilsarkom-Studiengruppe.
Hettmer S, Linardic CM, Kelsey A, Rudzinski ER, Vokuhl C, Selfe J, Ruhen O, Shern JF, Khan J, Kovach AR, Lupo PJ, Gatz SA, Schäfer BW, Volchenboum S, Minard-Colin V, Koscielniak E, Hawkins DS, Bisogno G, Sparber-Sauer M, Venkatramani R, Merks JHM, Shipley J. Hettmer S, et al. Eur J Cancer. 2022 Sep;172:367-386. doi: 10.1016/j.ejca.2022.05.036. Epub 2022 Jul 12. Eur J Cancer. 2022. PMID: 35839732 Free article. Review.
Risk stratification in European and North American clinical trials previously relied on clinico-pathological features, but now, incorporates PAX3/7-FOXO1-fusion gene status in the place of alveolar histology. International working groups propose a coordinated approa …
Risk stratification in European and North American clinical trials previously relied on clinico-pathological features, but now, incorporates …
Molecular diagnostics in the management of rhabdomyosarcoma.
Arnold MA, Barr FG. Arnold MA, et al. Expert Rev Mol Diagn. 2017 Feb;17(2):189-194. doi: 10.1080/14737159.2017.1275965. Epub 2017 Jan 6. Expert Rev Mol Diagn. 2017. PMID: 28058850 Free PMC article. Review.
A classification of rhabdomyosarcoma (RMS) with prognostic relevance has primarily relied on clinical features and histologic classification as either embryonal or alveolar RMS. The PAX3-FOXO1 and PAX7-FOXO1 gene fusions occur in 80% of cases with the alveola …
A classification of rhabdomyosarcoma (RMS) with prognostic relevance has primarily relied on clinical features and histologic classification …
Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs.
Manceau L, Richard Albert J, Lollini PL, Greenberg MVC, Gilardi-Hebenstreit P, Ribes V. Manceau L, et al. PLoS Genet. 2022 May 23;18(5):e1009782. doi: 10.1371/journal.pgen.1009782. eCollection 2022 May. PLoS Genet. 2022. PMID: 35604932 Free PMC article.
In addition, PAX7-FOXO1 binding results in greater recruitment of the H3K27ac activation mark than PAX3-FOXO1 binding and is accompanied by greater transcriptional activation of neighbouring genes. These effects are associated with a PAX-FOXO1-specific …
In addition, PAX7-FOXO1 binding results in greater recruitment of the H3K27ac activation mark than PAX3-FOXO1 binding and is a …
Rhabdomyosarcomas are oncogene addicted to the activation of AVIL.
Xie Z, Janczyk PL, Shi X, Wang Q, Singh S, Cornelison R, Xu J, Mandell JW, Barr FG, Li H. Xie Z, et al. Proc Natl Acad Sci U S A. 2022 Jun 14;119(24):e2118048119. doi: 10.1073/pnas.2118048119. Epub 2022 Jun 6. Proc Natl Acad Sci U S A. 2022. PMID: 37146302 Free PMC article.
Rhabdomyosarcoma (RMS) is one of the most common pediatric soft-tissue cancer. Previously, we discovered a gene fusion, MARS-AVIL formed by chromosomal inversion in RMS. Suspecting that forming a fusion with a housekeeping gene may be one of the mechanisms to dysreg …
Rhabdomyosarcoma (RMS) is one of the most common pediatric soft-tissue cancer. Previously, we discovered a gene fusion, MARS-AVIL for …
PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
Linardic CM. Linardic CM. Cancer Lett. 2008 Oct 18;270(1):10-8. doi: 10.1016/j.canlet.2008.03.035. Epub 2008 May 23. Cancer Lett. 2008. PMID: 18457914 Free PMC article. Review.
Of the two, aRMS is associated with an more aggressive disease pattern and a higher mortality, mandating a better understanding of this cancer at the molecular level. The PAX3-FOXO1 fusion gene, resulting from the stable reciprocal translocation of chromosomes 2 and …
Of the two, aRMS is associated with an more aggressive disease pattern and a higher mortality, mandating a better understanding of this canc …
Update on molecular findings in rhabdomyosarcoma.
El Demellawy D, McGowan-Jordan J, de Nanassy J, Chernetsova E, Nasr A. El Demellawy D, et al. Pathology. 2017 Apr;49(3):238-246. doi: 10.1016/j.pathol.2016.12.345. Epub 2017 Feb 27. Pathology. 2017. PMID: 28256213 Review.
There are several genes close to PAX that are frequently altered including the RAS family, FGFR4, PIK3CA, CTNNB1, FBXW7, and BCOR. As with most paediatric blue round cell tumours and sarcomas, chemotherapy is the key regimen for RMS therapy. Currently there are no direct i …
There are several genes close to PAX that are frequently altered including the RAS family, FGFR4, PIK3CA, CTNNB1, FBXW7, and BCOR. As …
Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in Rhabdomyosarcoma.
Nguyen TH, Barr FG. Nguyen TH, et al. Molecules. 2018 Oct 28;23(11):2798. doi: 10.3390/molecules23112798. Molecules. 2018. PMID: 30373318 Free PMC article. Review.
A specific chromosomal translocation t(2;13)(q35;q14) that gives rise to the chimeric oncogenic transcription factor PAX3-FOXO1 has been identified as a hallmark of the aggressive alveolar subtype of RMS. PAX3-FOXO1 cooperates with additional molecular changes to pr …
A specific chromosomal translocation t(2;13)(q35;q14) that gives rise to the chimeric oncogenic transcription factor PAX3-FOXO1 has b …
FOXO in B-cell lymphopoiesis and B cell neoplasia.
Ushmorov A, Wirth T. Ushmorov A, et al. Semin Cancer Biol. 2018 Jun;50:132-141. doi: 10.1016/j.semcancer.2017.07.008. Epub 2017 Jul 31. Semin Cancer Biol. 2018. PMID: 28774833 Review.
The activity of FOXOs is directly regulated both by signaling from B cell receptor (BCR) and cytokine receptors. FOXO1 action controls the transition between differentiation stages of B cell development. In comparison to other FOXO family members, FOXO1 plays a supe …
The activity of FOXOs is directly regulated both by signaling from B cell receptor (BCR) and cytokine receptors. FOXO1 action control …
1,196 results