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Curr Biol. 2004 Oct 26;14(20):R883-5.

tRNA maturation: RNA polymerization without a nucleic acid template.

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  • 1Department of Biochemistry, University of Washington, Box 357350, Seattle, Washington 98195-7350, USA.


The CCA-adding enzyme, which builds and repairs the 3' terminal CCA sequence of tRNA, is the only RNA polymerase that can synthesize a defined nucleotide sequence without using a nucleic acid template. New cocrystal structures tell us how this remarkable enzyme works.

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