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Results: 1 to 20 of 110


Targeted Inhibition of Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity.

Durrant DE, Das A, Dyer S, Tavallai S, Dent P, Kukreja RC.

Mol Pharmacol. 2015 Jun 22. pii: mol.115.099143. [Epub ahead of print]


Hydrogen sulfide mediates the cardioprotective effects of gene therapy with PKG-Iα.

Das A, Samidurai A, Hoke NN, Kukreja RC, Salloum FN.

Basic Res Cardiol. 2015 Jul;110(4):42. doi: 10.1007/s00395-015-0500-y. Epub 2015 Jun 3.


Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling.

Das A, Salloum FN, Filippone SM, Durrant DE, Rokosh G, Bolli R, Kukreja RC.

Basic Res Cardiol. 2015 May;110(3):31. doi: 10.1007/s00395-015-0486-5. Epub 2015 Apr 25.


Remote ischemic preconditioning for myocardial protection: update on mechanisms and clinical relevance.

Gill R, Kuriakose R, Gertz ZM, Salloum FN, Xi L, Kukreja RC.

Mol Cell Biochem. 2015 Apr;402(1-2):41-9. doi: 10.1007/s11010-014-2312-z. Epub 2015 Jan 1.


PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer.

Das A, Durrant D, Salloum FN, Xi L, Kukreja RC.

Pharmacol Ther. 2015 Mar;147:12-21. doi: 10.1016/j.pharmthera.2014.10.003. Epub 2014 Oct 31. Review.


Beetroot juice reduces infarct size and improves cardiac function following ischemia-reperfusion injury: Possible involvement of endogenous H2S.

Salloum FN, Sturz GR, Yin C, Rehman S, Hoke NN, Kukreja RC, Xi L.

Exp Biol Med (Maywood). 2015 May;240(5):669-81. doi: 10.1177/1535370214558024. Epub 2014 Oct 30.


Tadalafil prevents acute heart failure with reduced ejection fraction in mice.

Salloum FN, Chau VQ, Hoke NN, Kukreja RC.

Cardiovasc Drugs Ther. 2014 Dec;28(6):493-500. doi: 10.1007/s10557-014-6559-0.


Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice.

Toldo S, Das A, Mezzaroma E, Chau VQ, Marchetti C, Durrant D, Samidurai A, Van Tassell BW, Yin C, Ockaili RA, Vigneshwar N, Mukhopadhyay ND, Kukreja RC, Abbate A, Salloum FN.

Circ Cardiovasc Genet. 2014 Jun;7(3):311-20. doi: 10.1161/CIRCGENETICS.113.000381. Epub 2014 May 13.


Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling.

Koka S, Aluri HS, Xi L, Lesnefsky EJ, Kukreja RC.

Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1558-68. doi: 10.1152/ajpheart.00865.2013. Epub 2014 Apr 11.


PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells.

Roberts JL, Booth L, Conley A, Cruickshanks N, Malkin M, Kukreja RC, Grant S, Poklepovic A, Dent P.

Cancer Biol Ther. 2014 Jun 1;15(6):758-67. doi: 10.4161/cbt.28553. Epub 2014 Mar 20.


Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice.

Shalwala M, Zhu SG, Das A, Salloum FN, Xi L, Kukreja RC.

PLoS One. 2014 Jan 22;9(1):e86977. doi: 10.1371/journal.pone.0086977. eCollection 2014.


Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.

Das A, Durrant D, Koka S, Salloum FN, Xi L, Kukreja RC.

J Biol Chem. 2014 Feb 14;289(7):4145-60. doi: 10.1074/jbc.M113.521062. Epub 2013 Dec 26.


Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells.

Booth L, Roberts JL, Cruickshanks N, Conley A, Durrant DE, Das A, Fisher PB, Kukreja RC, Grant S, Poklepovic A, Dent P.

Mol Pharmacol. 2014 Mar;85(3):408-19. doi: 10.1124/mol.113.090043. Epub 2013 Dec 18.


Sildenafil and cardioprotection.

Kukreja RC.

Curr Pharm Des. 2013;19(39):6842-7. Review.


Krüppel-like factor 2 is required for normal mouse cardiac development.

Chiplunkar AR, Lung TK, Alhashem Y, Koppenhaver BA, Salloum FN, Kukreja RC, Haar JL, Lloyd JA.

PLoS One. 2013;8(2):e54891. doi: 10.1371/journal.pone.0054891. Epub 2013 Feb 14.


Phosphodiesterase-5 inhibitor tadalafil attenuates oxidative stress and protects against myocardial ischemia/reperfusion injury in type 2 diabetic mice.

Koka S, Das A, Salloum FN, Kukreja RC.

Free Radic Biol Med. 2013 Jul;60:80-8. doi: 10.1016/j.freeradbiomed.2013.01.031. Epub 2013 Feb 4.


Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice.

Varma A, Das A, Hoke NN, Durrant DE, Salloum FN, Kukreja RC.

PLoS One. 2012;7(9):e45243. doi: 10.1371/journal.pone.0045243. Epub 2012 Sep 21.


Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway.

Das A, Salloum FN, Durrant D, Ockaili R, Kukreja RC.

J Mol Cell Cardiol. 2012 Dec;53(6):858-69. doi: 10.1016/j.yjmcc.2012.09.007. Epub 2012 Sep 19.


Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection.

Kukreja RC, Salloum FN, Das A.

J Am Coll Cardiol. 2012 May 29;59(22):1921-7. doi: 10.1016/j.jacc.2011.09.086. Review.


Dietary inorganic nitrate alleviates doxorubicin cardiotoxicity: mechanisms and implications.

Xi L, Zhu SG, Das A, Chen Q, Durrant D, Hobbs DC, Lesnefsky EJ, Kukreja RC.

Nitric Oxide. 2012 May 15;26(4):274-84. doi: 10.1016/j.niox.2012.03.006. Epub 2012 Apr 5. Review.

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