Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive impairments in memory and cognition. Extracellular accumulation of soluble high-molecular-weight (HMW) Abeta oligomers has been proposed to be largely responsible for AD dementia and memory deficits in the Tg2576 mice, a model of AD. In this study, we found that a naturally derived grape seed polyphenolic extract can significantly inhibit amyloid beta-protein aggregation into high-molecular-weight oligomers in vitro. When orally administered to Tg2576 mice, this polyphenolic preparation significantly attenuates AD-type cognitive deterioration coincidentally with reduced HMW soluble oligomeric Abeta in the brain. Our study suggests that grape seed-derived polyphenolics may be useful agents to prevent or treat AD.
Publication types
-
Comparative Study
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Alzheimer Disease / metabolism
-
Alzheimer Disease / pathology
-
Alzheimer Disease / prevention & control*
-
Amyloid beta-Peptides / antagonists & inhibitors*
-
Amyloid beta-Peptides / metabolism
-
Animals
-
Cognition Disorders / metabolism
-
Cognition Disorders / pathology
-
Cognition Disorders / prevention & control*
-
Disease Models, Animal
-
Female
-
Flavonoids / isolation & purification
-
Flavonoids / therapeutic use*
-
Male
-
Mice
-
Mice, Transgenic
-
Phenols / isolation & purification
-
Phenols / therapeutic use*
-
Plant Extracts / isolation & purification
-
Plant Extracts / therapeutic use
-
Polyphenols
-
Vitis*
Substances
-
Amyloid beta-Peptides
-
Flavonoids
-
Phenols
-
Plant Extracts
-
Polyphenols