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Page 1
Matrix Metalloproteinase Inhibition in a Murine Model of Cavitary Tuberculosis Paradoxically Worsens Pathology.
Ordonez AA, Pokkali S, Sanchez-Bautista J, Klunk MH, Urbanowski ME, Kübler A, Bishai WR, Elkington PT, Jain SK. Ordonez AA, et al. J Infect Dis. 2019 Jan 29;219(4):633-636. doi: 10.1093/infdis/jiy373. J Infect Dis. 2019. PMID: 29920600 Free PMC article.
In particular, MMP-7 is induced by hypoxia and highly expressed around pulmonary cavities of Mycobacterium tuberculosis-infected C3HeB/FeJ mice. In this study, we evaluated whether administration of cipemastat, an orally available potent inhibitor of MMP-7, could reduce pu …
In particular, MMP-7 is induced by hypoxia and highly expressed around pulmonary cavities of Mycobacterium tuberculosis-infected C3HeB/FeJ m …
Tumor cell density regulates matrix metalloproteinases for enhanced migration.
Jayatilaka H, Umanzor FG, Shah V, Meirson T, Russo G, Starich B, Tyle P, Lee JSH, Khatau S, Gil-Henn H, Wirtz D. Jayatilaka H, et al. Oncotarget. 2018 Aug 24;9(66):32556-32569. doi: 10.18632/oncotarget.25863. eCollection 2018 Aug 24. Oncotarget. 2018. PMID: 30220965 Free PMC article.
Local tumor cell density also plays a role in the responsiveness of cells to matrix metalloproteinases inhibitors (MMPI), such as Batimastat, Marimastat, Bryostatin I, and Cipemastat, where different migratory phenotypes are observed in low and high cell density conditions …
Local tumor cell density also plays a role in the responsiveness of cells to matrix metalloproteinases inhibitors (MMPI), such as Batimastat …
Repetitive Aerosol Exposure Promotes Cavitary Tuberculosis and Enables Screening for Targeted Inhibitors of Extensive Lung Destruction.
Urbanowski ME, Ihms EA, Bigelow K, Kübler A, Elkington PT, Bishai WR. Urbanowski ME, et al. J Infect Dis. 2018 Jun 5;218(1):53-63. doi: 10.1093/infdis/jiy127. J Infect Dis. 2018. PMID: 29554286 Free PMC article.
Necropsies confirmed greater lung pathology in repetitively exposed animals. For cipemastat-treated animals, there was no significant difference in cavity counts, cavity volume, or disease severity compared to controls. ...This suggests that human lung destruction due to t …
Necropsies confirmed greater lung pathology in repetitively exposed animals. For cipemastat-treated animals, there was no significant …
Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis.
Liechti FD, Grandgirard D, Leppert D, Leib SL. Liechti FD, et al. Infect Immun. 2014 Apr;82(4):1710-8. doi: 10.1128/IAI.00073-14. Epub 2014 Feb 3. Infect Immun. 2014. PMID: 24491581 Free PMC article.
Here, we evaluated two second-generation MMP and TACE inhibitors with higher selectivity and improved oral availability. Ro 32-3555 (Trocade, cipemastat) preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9), while Ro 32-7315 is an efficient in …
Here, we evaluated two second-generation MMP and TACE inhibitors with higher selectivity and improved oral availability. Ro 32-3555 (Trocade …
Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones.
Yin Z, Sada AA, Reslan OM, Narula N, Khalil RA. Yin Z, et al. Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E55-70. doi: 10.1152/ajpendo.00553.2011. Epub 2012 Apr 10. Am J Physiol Endocrinol Metab. 2012. PMID: 22496348 Free PMC article.
Pretreatment with the MMP inhibitors SB-3CT (MMP-2/MMP-9 Inhibitor IV), BB-94 (batimastat), or Ro-28-2653 (cipemastat) enhanced contraction in myometrium of pregnant rats. RT-PCR, Western blot analysis, and gelatin zymography demonstrated increased mRNA expression, protein …
Pretreatment with the MMP inhibitors SB-3CT (MMP-2/MMP-9 Inhibitor IV), BB-94 (batimastat), or Ro-28-2653 (cipemastat) enhanced contr …