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Results: 1 to 20 of 96

1.

Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillance.

Korsse SE, Harinck F, van Lier MG, Biermann K, Offerhaus GJ, Krak N, Looman CW, van Veelen W, Kuipers EJ, Wagner A, Dekker E, Mathus-Vliegen EM, Fockens P, van Leerdam ME, Bruno MJ.

J Med Genet. 2013 Jan;50(1):59-64. doi: 10.1136/jmedgenet-2012-101277.

PMID:
23240097
[PubMed - indexed for MEDLINE]
2.

Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.

Tanwar PS, Kaneko-Tarui T, Zhang L, Teixeira JM.

Hum Mol Genet. 2012 Oct 15;21(20):4394-405. Epub 2012 Jul 12.

PMID:
22791749
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.

Jaeger E, Leedham S, Lewis A, Segditsas S, Becker M, Cuadrado PR, Davis H, Kaur K, Heinimann K, Howarth K, East J, Taylor J, Thomas H, Tomlinson I.

Nat Genet. 2012 May 6;44(6):699-703. doi: 10.1038/ng.2263.

PMID:
22561515
[PubMed - indexed for MEDLINE]
4.

Peutz-Jeghers syndrome: intriguing suggestion of gastrointestinal cancer prevention from surveillance.

Latchford AR, Neale K, Phillips RK, Clark SK.

Dis Colon Rectum. 2011 Dec;54(12):1547-51. doi: 10.1097/DCR.0b013e318233a11f.

PMID:
22067184
[PubMed - indexed for MEDLINE]
5.

Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1.

Gaude H, Aznar N, Delay A, Bres A, Buchet-Poyau K, Caillat C, Vigouroux A, Rogon C, Woods A, Vanacker JM, Höhfeld J, Perret C, Meyer P, Billaud M, Forcet C.

Oncogene. 2012 Mar 22;31(12):1582-91. doi: 10.1038/onc.2011.342. Epub 2011 Aug 22.

PMID:
21860411
[PubMed - indexed for MEDLINE]
6.

LKB1 signaling in advancing cell differentiation.

Udd L, Mäkelä TP.

Fam Cancer. 2011 Sep;10(3):425-35. doi: 10.1007/s10689-011-9441-2. Review.

PMID:
21519908
[PubMed - indexed for MEDLINE]
7.

Case studies in the diagnosis and management of Peutz-Jeghers syndrome.

Riegert-Johnson D, Roberts M, Gleeson FC, Krishna M, Boardman L.

Fam Cancer. 2011 Sep;10(3):463-8. doi: 10.1007/s10689-011-9438-x.

PMID:
21503748
[PubMed - indexed for MEDLINE]
8.

mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome.

Klümpen HJ, Queiroz KC, Spek CA, van Noesel CJ, Brink HC, de Leng WW, de Wilde RF, Mathus-Vliegen EM, Offerhaus GJ, Alleman MA, Westermann AM, Richel DJ.

J Clin Oncol. 2011 Feb 20;29(6):e150-3. doi: 10.1200/JCO.2010.32.7825. Epub 2010 Dec 28. No abstract available.

PMID:
21189378
[PubMed - indexed for MEDLINE]
Free Article
9.

High cumulative risk of intussusception in patients with Peutz-Jeghers syndrome: time to update surveillance guidelines?

van Lier MG, Mathus-Vliegen EM, Wagner A, van Leerdam ME, Kuipers EJ.

Am J Gastroenterol. 2011 May;106(5):940-5. doi: 10.1038/ajg.2010.473. Epub 2010 Dec 14.

PMID:
21157440
[PubMed - indexed for MEDLINE]
10.

Peutz-Jeghers syndrome: a systematic review and recommendations for management.

Beggs AD, Latchford AR, Vasen HF, Moslein G, Alonso A, Aretz S, Bertario L, Blanco I, Bülow S, Burn J, Capella G, Colas C, Friedl W, Møller P, Hes FJ, Järvinen H, Mecklin JP, Nagengast FM, Parc Y, Phillips RK, Hyer W, Ponz de Leon M, Renkonen-Sinisalo L, Sampson JR, Stormorken A, Tejpar S, Thomas HJ, Wijnen JT, Clark SK, Hodgson SV.

Gut. 2010 Jul;59(7):975-86. doi: 10.1136/gut.2009.198499.

PMID:
20581245
[PubMed - indexed for MEDLINE]
11.

A prospective study of MR enterography versus capsule endoscopy for the surveillance of adult patients with Peutz-Jeghers syndrome.

Gupta A, Postgate AJ, Burling D, Ilangovan R, Marshall M, Phillips RK, Clark SK, Fraser CH.

AJR Am J Roentgenol. 2010 Jul;195(1):108-16. doi: 10.2214/AJR.09.3174.

PMID:
20566803
[PubMed - indexed for MEDLINE]
12.

Alu-mediated genomic deletion of the serine/threonine protein kinase 11 (STK11) gene in Peutz-Jeghers syndrome.

De Rosa M, Galatola M, Quaglietta L, Miele E, De Palma G, Rossi GB, Staiano A, Izzo P.

Gastroenterology. 2010 Jun;138(7):2558-60. doi: 10.1053/j.gastro.2010.03.061. No abstract available.

PMID:
20435009
[PubMed - indexed for MEDLINE]
13.

Pharmacotherapy for inherited colorectal cancer.

Lynch PM.

Expert Opin Pharmacother. 2010 May;11(7):1101-8. doi: 10.1517/14656561003698123. Review.

PMID:
20345333
[PubMed - indexed for MEDLINE]
14.

Endoscopic therapy of small-bowel polyps by double-balloon enteroscopy in patients with Peutz-Jeghers syndrome.

Gao H, van Lier MG, Poley JW, Kuipers EJ, van Leerdam ME, Mensink PB.

Gastrointest Endosc. 2010 Apr;71(4):768-73. doi: 10.1016/j.gie.2009.11.005. Epub 2010 Feb 25.

PMID:
20188368
[PubMed - indexed for MEDLINE]
15.

High cancer risk in Peutz-Jeghers syndrome: a systematic review and surveillance recommendations.

van Lier MG, Wagner A, Mathus-Vliegen EM, Kuipers EJ, Steyerberg EW, van Leerdam ME.

Am J Gastroenterol. 2010 Jun;105(6):1258-64; author reply 1265. doi: 10.1038/ajg.2009.725. Epub 2010 Jan 5. Review.

PMID:
20051941
[PubMed - indexed for MEDLINE]
16.

Truncating mutations in Peutz-Jeghers syndrome are associated with more polyps, surgical interventions and cancers.

Salloch H, Reinacher-Schick A, Schulmann K, Pox C, Willert J, Tannapfel A, Heringlake S, Goecke TO, Aretz S, Stemmler S, Schmiegel W.

Int J Colorectal Dis. 2010 Jan;25(1):97-107. doi: 10.1007/s00384-009-0793-0. Epub 2009 Sep 2.

PMID:
19727776
[PubMed - indexed for MEDLINE]
17.

Oral rapamycin reduces tumour burden and vascularization in Lkb1(+/-) mice.

Robinson J, Lai C, Martin A, Nye E, Tomlinson I, Silver A.

J Pathol. 2009 Sep;219(1):35-40. doi: 10.1002/path.2562.

PMID:
19434632
[PubMed - indexed for MEDLINE]
18.

Somatic LKB1 mutations promote cervical cancer progression.

Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T, Shimamura T, Miller DS, Sharpless NE, Bardeesy N, Kwiatkowski DJ, Schorge JO, Wong KK, Castrillon DH.

PLoS One. 2009;4(4):e5137. doi: 10.1371/journal.pone.0005137. Epub 2009 Apr 2.

PMID:
19340305
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model.

Wei C, Amos CI, Zhang N, Zhu J, Wang X, Frazier ML.

Cancer Lett. 2009 May 18;277(2):149-54. doi: 10.1016/j.canlet.2008.11.036. Epub 2009 Jan 14.

PMID:
19147279
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The mTOR inhibitor rapamycin significantly improves facial angiofibroma lesions in a patient with tuberous sclerosis.

Hofbauer GF, Marcollo-Pini A, Corsenca A, Kistler AD, French LE, Wüthrich RP, Serra AL.

Br J Dermatol. 2008 Aug;159(2):473-5. doi: 10.1111/j.1365-2133.2008.08677.x. Epub 2008 Jun 28.

PMID:
18547304
[PubMed - indexed for MEDLINE]

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