Biochemistry. 1976 Dec 14;15(25):5627-31.

Free-energy profile of the reaction catalyzed by triosephosphate isomerase.

Abstract

The experimental results on the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate catalyzed by triosephosphate isomerase that are presented in the previous five papers are here collected and analyzed according to the theory presented in the first paper (Albery, W.J., Knowles, J.R. (1976), Biochemistry 15, the first of eight papers in a series in this issue). The rate constants and fractionation factors so derived allow the construction of theGibbs free-energy profile for this enzyme-catalyzed reaction.

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Energetics of triosephosphate isomerase: deuterium isotope effects in the enzyme-catalyzed reaction. [Biochemistry. 1976]
Energetics of triosephosphate isomerase: deuterium isotope effects in the enzyme-catalyzed reaction.
Leadlay PF, Albery WJ, Knowles JR. Biochemistry. 1976 Dec 14; 15(25):5617-20.
Energetics of triosephosphate isomerase: the appearance of solvent tritium in substrate dihydroxyacetone phosphate and in product. [Biochemistry. 1976]
Energetics of triosephosphate isomerase: the appearance of solvent tritium in substrate dihydroxyacetone phosphate and in product.
Maister SG, Pett CP, Albery WJ, Knowles JR. Biochemistry. 1976 Dec 14; 15(25):5607-12.
The uncatalyzed rates of enolization of dihydroxyacetone phoshate and of glyceraldehyde 3-phosphate in neutral aqueous solution. The quantitative assessment of the effectiveness of an enzyme catalyst. [Biochemistry. 1975]
The uncatalyzed rates of enolization of dihydroxyacetone phoshate and of glyceraldehyde 3-phosphate in neutral aqueous solution. The quantitative assessment of the effectiveness of an enzyme catalyst.
Hall A, Knowles JR. Biochemistry. 1975 Sep 23; 14(19):4348-53.
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Alber T, Banner DW, Bloomer AC, Petsko GA, Phillips D, Rivers PS, Wilson IA. Philos Trans R Soc Lond B Biol Sci. 1981 Jun 26; 293(1063):159-71.
Review Mechanism for the formation of methylglyoxal from triosephosphates. [Biochem Soc Trans. 1993]
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Free-energy profile of the reaction catalyzed by triosephosphate isomerase.
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Biochemistry. 1976 Dec 14 ;15(25):5627-31.

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