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Exp Eye Res. 1998 Dec;67(6):619-24.

Production of key molecules by ocular neutrophils early after herpetic infection of the cornea.

Author information

  • 1Department of Microbiology, University of Tennessee, Knoxville 37996-0845, USA.

Abstract

Herpes simplex virus infection of the eye can result in a blinding inflammatory lesion that is a T cell mediated immunopathological reaction. A prominent early event following HSV infection is neutrophil invasion of the corneal stroma. These cells may be involved in viral clearance and may influence the nature of the anti HSV T cell response which subsequently occurs. This article measures the expression of some key molecules which could participate in viral clearance and immune modulation. Using RT-PCR and in-situ hybridization, both corneal and peritoneal neutrophils were shown to be sources of iNOS and TNF alpha molecules which likely contribute to antiviral activity. Neutrophils also produce the cytokine IL-12, a key molecule which modulates the CD4+ T cell response to a type which mediates immunopathology. The present results indicate that neutrophils play an important role in the pathogenesis of herpetic ocular lesions.

PMID:
9990326
[PubMed - indexed for MEDLINE]
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