FEBS Lett. 1999 Jan 25;443(2):121-5.

Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.

Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR.

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Division of Biomedical Sciences, Randall Institute, King's College, London, UK.

Abstract

Treatment of herpes infections with nucleoside analogues requires as an initial step the activation of the compounds by thymidine kinase. As an aid to developing more effective chemotherapy, both for treatment of recurrent herpes infection and in gene therapy systems where thymidine kinase is expressed, two high-resolution X-ray structures of thymidine kinase have been compared: one with the relatively poor substrate aciclovir (Zovirax), the other with a synthetic inhibitor having an N2-substituted guanine. Both compounds have similar binding modes in spite of their size difference and apparently distinct ligand properties.

PMID:: 9989588; [PubMed - indexed for MEDLINE]

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Cited by 3 PubMed Central articles

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Structures reported by this article

Herpes Simplex Virus Type-I Thymidine Kinase Complexed With A Novel Non-Substrate Inhibitor, 9-(4-Hydroxybutyl)-N2- Phenylguanine

PDB: 1QHI

Source: Human herpesvirus 1

Method: X-Ray Diffraction

Resolution: 1.9 Å

See all 2 structures...

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