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Identification of a neural stem cell in the adult mammalian central nervous system.
Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
New neurons are continuously added in specific regions of the adult mammalian central nervous system. These neurons are derived from multipotent stem cells whose identity has been enigmatic. In this work, we present evidence that ependymal cells are neural stem cells. Ependymal cells give rise to a rapidly proliferating cell type that generates neurons that migrate to the olfactory bulb. In response to spinal cord injury, ependymal cell proliferation increases dramatically to generate migratory cells that differentiate to astrocytes and participate in scar formation. These data demonstrate that ependymal cells are neural stem cells and identify a novel process in the response to central nervous system injury.
PMID: 9989494 [PubMed - indexed for MEDLINE]
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Cited by 74 PubMed Central articles
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Stem cells, phenotypic inversion, and differentiation.
Siggins RW, Zhang P, Welsh D, Lecapitaine NJ, Nelson S.
Int J Clin Exp Med. 2008; 1(1):2-21. Epub 2008 Jan 20.
[Int J Clin Exp Med. 2008]
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Electrophysiological properties of mouse cortical neuron progenitors differentiated in vitro and in vivo.
Wang W, Jin K, Mao XO, Close N, Greenberg DA, Xiong ZG.
Int J Clin Exp Med. 2008; 1(2):145-53. Epub 2008 Mar 6.
[Int J Clin Exp Med. 2008]
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Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damage.
Wei D, Levic S, Nie L, Gao WQ, Petit C, Jones EG, Yamoah EN.
Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):21000-5. Epub 2008 Dec 8.
[Proc Natl Acad Sci U S A. 2008]
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