Nat Genet. 1999 Feb;21(2):163-7.

Cancer epigenetics comes of age.

Source

Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, The Norris Comprehensive Cancer Center, Los Angeles 90033, USA. jones_p@froggy.hsc.usc.edu

Abstract

The discovery of numerous hypermethylated promoters of tumour-suppressor genes, along with a better understanding of gene-silencing mechanisms, has moved DNA methylation from obscurity to recognition as an alternative mechanism of tumour-suppressor inactivation in cancer. Epigenetic events can also facilitate genetic damage, as illustrated by the increased mutagenicity of 5-methylcytosine and the silencing of the MLH1 mismatch repair gene by DNA methylation in colorectal tumours. We review here current mechanistic understanding of the role of DNA methylation in malignant transformation, and suggest Knudson's two-hit hypothesis should now be expanded to include epigenetic mechanisms of gene inactivation.

PMID:: 9988266; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Cancer - MedlinePlus Health Information

Supplemental Content

Related citations

Review DNA methylation, imprinting and cancer. [Eur J Hum Genet. 2002]
Review DNA methylation, imprinting and cancer.
Plass C, Soloway PD. Eur J Hum Genet. 2002 Jan; 10(1):6-16.
Review Dormant hypermethylated tumour suppressor genes: questions and answers. [J Pathol. 2005]
Review Dormant hypermethylated tumour suppressor genes: questions and answers.
Esteller M. J Pathol. 2005 Jan; 205(2):172-80.
Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer. [Br J Cancer. 2002]
Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer.
Deng G, Peng E, Gum J, Terdiman J, Sleisenger M, Kim YS. Br J Cancer. 2002 Feb 12; 86(4):574-9.
Review [Cancer epigenetics]. [Korean J Gastroenterol. 2004]
Review [Cancer epigenetics].
Chang DK. Korean J Gastroenterol. 2004 Jul; 44(1):1-12.
Review DNA hypermethylation: when tumour suppressor genes go silent. [Hum Genet. 2002]
Review DNA hypermethylation: when tumour suppressor genes go silent.
Garinis GA, Patrinos GP, Spanakis NE, Menounos PG. Hum Genet. 2002 Aug; 111(2):115-27. Epub 2002 Jul 16.

See reviews... See all...

Cited by over 100 PubMed Central articles

DNA methylation: a timeline of methods and applications. [Front Genet. 2011]
DNA methylation: a timeline of methods and applications.
Harrison A, Parle-McDermott A. Front Genet. 2011; 2:74. Epub 2011 Oct 25.
Biological Basis of Differential Susceptibility to Hepatocarcinogenesis among Mouse Strains. [J Toxicol Pathol. 2009]
Biological Basis of Differential Susceptibility to Hepatocarcinogenesis among Mouse Strains.
Maronpot RR. J Toxicol Pathol. 2009 Mar; 22(1):11-33. Epub 2009 Apr 6.
Genome-scale screen for DNA methylation-based detection markers for ovarian cancer. [PLoS One. 2011]
Genome-scale screen for DNA methylation-based detection markers for ovarian cancer.
Campan M, Moffitt M, Houshdaran S, Shen H, Widschwendter M, Daxenbichler G, Long T, Marth C, Laird-Offringa IA, Press MF, et al. PLoS One. 2011; 6(12):e28141. Epub 2011 Dec 7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cancer epigenetics comes of age.
Cancer epigenetics comes of age.
Nat Genet. 1999 Feb ;21(2):163-7.

PubMed
Effects of marijuana on testosterone in male subjects.
Effects of marijuana on testosterone in male subjects.
J Theor Biol. 1983 Oct 21 ;104(4):685-92.

PubMed
Is your prescription of distance running shoes evidence-based?
Is your prescription of distance running shoes evidence-based?
Br J Sports Med. 2009 Mar ;43(3):159-62. Epub 2008 Apr 18 .

PubMed
Multiple alternative splicing markers for ovarian cancer.
Multiple alternative splicing markers for ovarian cancer.
Cancer Res. 2008 Feb 1 ;68(3):657-63.

PubMed
Antibody-dependent cell-mediated cytotoxic responses in participants enrolled in...
Antibody-dependent cell-mediated cytotoxic responses in participants enrolled in a phase I/II ALVAC-HIV/AIDSVAX B/E prime-boost HIV-1 vaccine trial in Thailand.
Vaccine. 2005 Mar 31 ;23(19):2522-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: