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1: Vaccine. 1999 Jan 28;17(4):340-4.Click here to read Links

Protection against anthrax toxin by vaccination with a DNA plasmid encoding anthrax protective antigen.

Gu ML, Leppla SH, Klinman DM.

Section of Retroviral Immunology, Food and Drug Administration, Bethesda, MD, USA.

A DNA vaccine encoding the immunogenic and biologically active portion of anthrax protective antigen (PA) was constructed. Spleen cells from BALB/c mice immunized intramuscularly with this vaccine were stimulated to secrete IFN gamma and IL-4 when exposed to PA in vitro. Immunized mice also mounted a humoral immune response dominated by IgG1 anti-PA antibody production, the subclass previously shown to confer protection against anthrax toxin. A 1:100 dilution of serum from these animals protected cells in vitro against cytotoxic concentrations of PA. Moreover, 7/8 mice immunized three times with the PA DNA vaccine were protected against lethal challenge with a combination of anthrax protective antigen plus lethal factor.

PMID: 9987172 [PubMed - indexed for MEDLINE]

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